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The fingerprint of Verbenae Herba was established and the contents of four effective components were determined to provide reference for the quality control of Verbenae Herba. The fingerprint of Verbenae Herba was established by ultra performance liquid chromatography(UPLC)method, and the common peaks were identified by high resolution mass spectrometry. The relative peak areas of the common peaks in the fingerprints of 15 batches of Verbenae Herba were used as variables for chemometric analysis, and the contents of the effective components of hastatoside, verbenoside, acteoside and isoacteoside in 15 batches of Verbenae Herba were determined. The results showed that there were 16 common peaks in the fingerprint of Verbenae Herba, and six of them were identified. Cluster analysis(HCA) and principal component analysis(PCA) divided 15 batches of medicinal materials into three …

Background
The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied.

Methods
In a multicenter trial in China, we enrolled patients with ischemic stroke without occlusion of large or medium-sized vessels and with a National Institutes of Health Stroke Scale score of 5 or more and at least one moderately to severely weak limb. Eligible patients had any of four clinical presentations: ineligible for thrombolysis or thrombectomy and within 24 hours after the patient was last known to be well; progression of stroke symptoms 24 to 96 hours after onset; early neurologic deterioration after thrombolysis; or thrombolysis with no improvement at 4 to 24 hours. Patients were assigned to receive intravenous tirofiban (plus oral placebo) or oral aspirin (100 mg per day …

Background
The effect of imaging selection paradigms on endovascular thrombectomy outcomes in patients with acute ischemic stroke with large vessel occlusion remains uncertain. The study aimed to assess the effect of basic imaging (noncontrast computed tomography with or without computed tomographic angiography) versus advanced imaging (magnetic resonance imaging or computed tomography perfusion) on clinical outcomes following thrombectomy in patients with stroke with large vessel occlusion in the early and extended windows using a pooled analysis of patient-level data from 2 pivotal randomized clinical trials done in China.

Methods
This post hoc analysis used data from 1182 patients included in 2 multicenter, randomized controlled trials in China that evaluated adjunct therapies to endovascular treatment for acute ischemic stroke (Direct Endovascular Treatment for Large Artery Anterior …

Microplastics, as a new type of pollutant, are widely present in various environmental media. The contamination of microplastics in soil environments has attracted global attention. The theme of this study revolves the contamination of microplastics in agricultural soil. Based on a summary and analysis of the latest research progress at home and abroad, a review was made of the impact of microplastics on the physicochemical properties of agricultural soil, soil microbial biomass, microbial community structure and function. Microplastics that enter agricultural soil through agricultural activities and other pathways will undergo weathering and degradation under non-biological and biological processes, and affect soil physicochemical properties, nutrient cycling, and the interaction of pollutants, thereby affecting soil microbial biomass, microbial community structure and diversity, soil enzyme activity, and soil biogeochemical processes such as carbon and nitrogen cycling, as well as pollutants degradation. The impacts of microplastics on the above indicators are related to various factors such as the properties of microplastics, soil type, and exposure conditions. This paper provides a prospect for future research directions on microplastics in soil, in the hope of providing reference and ideas for future research.