Empowering Discovery,
Enhancing Knowledge

Privacy and ethical considerations limit access to large-scale clinical datasets, particularly clinical text data, which contain extensive and diverse information and serve as the foundation for building clinical large language models (LLMs). The limited accessibility of clinical text data impedes the development of clinical artificial intelligence systems and hampers research participation from resource-poor regions and medical institutions, thereby exacerbating health care disparities. In this review, we conduct a global review to identify publicly available clinical text datasets and elaborate on their accessibility, diversity, and usability for clinical LLMs. We screened 3962 papers across medical (PubMed and MEDLINE) and computational linguistic academic databases (the Association for Computational Linguistics Anthology) as well as 239 tasks from prevalent medical natural language processing (NLP) challenges, such …

Modern Knowledge Graphs (KGs) are inevitably noisy due to the nature of their construction process. Existing robust learning techniques for noisy KGs mostly focus on triple facts, where the fact-wise confidence is straightforward to evaluate. However, hyper-relational facts, where an arbitrary number of key-value pairs are associated with a base triplet, have become increasingly popular in modern KGs, but significantly complicate the confidence assessment of the fact. Against this background, we study the problem of robust link prediction over noisy hyper-relational KGs, and propose NYLON, a \underlineN oise-resistant h\underlineY per-re\underlineL ati\underlineON al link prediction technique via active crowd learning. Specifically, beyond the traditional fact-wise confidence, we first introduce element-wise confidence measuring the fine-grained confidence of each entity or relation of a hyper-relational fact. We …

Clinicians increasingly pay attention to Artificial Intelligence (AI) to improve the quality and timeliness of their services. There are converging opinions on the need for Explainable AI (XAI) in healthcare. However, prior work considers explanations as stationary entities with no account for the temporal dynamics of patient care. In this work, we involve 16 Idiopathic Pulmonary Fibrosis (IPF) clinicians from a European university medical centre and investigate their evolving uses and purposes for explainability throughout patient care. By applying a patient journey map for IPF, we elucidate clinicians’ informational needs, how human agency and patient-specific conditions can influence the interaction with XAI systems, and the content, delivery, and relevance of explanations over time. We discuss implications for integrating XAI in clinical contexts and more broadly how explainability is defined and evaluated. Furthermore …

Objectives
Large Language Models (LLMs) such as ChatGPT and Med-PaLM have excelled in various medical question-answering tasks. However, these English-centric models encounter challenges in non-English clinical settings, primarily due to limited clinical knowledge in respective languages, a consequence of imbalanced training corpora. We systematically evaluate LLMs in the Chinese medical context and develop a novel in-context learning framework to enhance their performance.

Materials and Methods
The latest China National Medical Licensing Examination (CNMLE-2022) served as the benchmark. We collected 53 medical books and 381 149 medical questions to construct the medical knowledge base and question bank. The proposed Knowledge and Few-shot Enhancement In-context Learning (KFE) framework leverages the in-context learning ability of …